
Manganese(salen) chloride
CAS No. 53177-12-1
Manganese(salen) chloride ( EUK-8 )
产品货号. M28316 CAS No. 53177-12-1
氯化锰 (Salen) (EUK-8) 是一种超氧化物歧化酶和过氧化氢酶模拟物,是一种具有氧自由基清除特性的抗氧化剂。氯化锰(萨伦)可改善内毒素血症猪的急性肺损伤。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥316 | 有现货 |
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25MG | ¥502 | 有现货 |
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50MG | ¥737 | 有现货 |
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100MG | ¥1077 | 有现货 |
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200MG | ¥1596 | 有现货 |
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500MG | ¥2697 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称Manganese(salen) chloride
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述氯化锰 (Salen) (EUK-8) 是一种超氧化物歧化酶和过氧化氢酶模拟物,是一种具有氧自由基清除特性的抗氧化剂。氯化锰(萨伦)可改善内毒素血症猪的急性肺损伤。
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产品描述Manganese(salen) chloride (EUK-8), a superoxide dismutase and catalase mimetic, is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine.(In Vitro):Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation. (In Vivo):Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant . Animal Model: Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage: 25 mg/kg/day Administration: I.p. 3 times a week for 4 weeks Result: Prevented myocardial oxidant damage provoked by biomechanical stress. Improved survival following biomechanical stress. Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
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体外实验Manganese(salen) chloride (25 μM; 24-72 h) protects organotypic hippocampal slices from β-AP-induced neurotoxicity, and completely blocks β-AP-induced free radical accumulation and lipid peroxidation.
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体内实验Manganese(salen) chloride (25 mg/kg; i.p. 3 times a week for 4 weeks) reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. Animal Model:Wild-type (WT) and harlequin (Hq) B6CBA male and female mice Dosage:25 mg/kg/day Administration:I.p. 3 times a week for 4 weeksResult:Prevented myocardial oxidant damage provoked by biomechanical stress.Improved survival following biomechanical stress.Prevented functional and geometrical deterioration in response to pressure overload. Attenuated necrotic and apoptotic cell death, and attenuated cardiac hypertrophy and fibrosis.
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同义词EUK-8
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通路Others
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靶点Other Targets
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受体monophenolase
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研究领域——
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适应症——
化学信息
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CAS Number53177-12-1
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分子量356.69
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分子式C16H14ClMnN2O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 8.33 mg/mL (23.35 mM)
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SMILES[Cl-].[Mn+5].[O-]c1ccccc1\C=[N-]\CC\[N-]=C/c1ccccc1[O-]
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Fu B, et al. Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. J Agric Food Chem. 2005 Sep 21;53(19):7408-14.
产品手册




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